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SPARK Microsystems to Demonstrate Bit-Perfect Wireless Audio Delivery at AES Show 2024 NY

SPARK Microsystems

SPARK Microsystems, a Canadian fabless semiconductor company specializing in next-generation short-range wireless communications, will showcase an industry-first breakthrough in wireless audio delivery at AES Show 2024 NY (October 8 -10, Jacob Javits Convention Center, New York). At the event, SPARK will share the results of an exhaustive third-party expert analysis comparing SPARK ultra-wideband (UWB) digital audio performance versus the performance delivered with a digital wire. On Thursday, October 10, 11AM in Demo Room 3D04, audio industry expert Jeff Anderson will present an audio transmission data comparison of UWB and straight S/PDIF wire links at data rates up to 24 bits and 96Ks/s. In a major breakthrough for the audio industry and a giant leap beyond legacy Bluetooth wireless, the results will show that SPARK UWB audio delivery is indistinguishable from a wired transmission, exhibiting bit-perfect fidelity. Data shows that the SPARK UWB transmission scheme delivers a pristine, uncorrupted audio bit depth at ultra-low latency. Headsets, speakers and audio equipment harnessing this bit-perfect performance profile can deliver wired-like sound quality – without the wires. AES Show 2024 NY attendees are invited to experience SPARK’s breakthrough wireless audio quality for themselves via demonstrations of SPARK’s headset demo kit. Delivering pristine uncompressed 96kHz 24-bit audio quality, the SPARK UWB audio technology featured in the headset design ensures that listeners can enjoy their music and entertainment with flawless sound fidelity. SPARK’s headset demo kit offers support for up to 96kHz stereo audio and a 48kHz 16-bit microphone back channel with an impressive low latency of sub-7ms, making the technology ideal for applications where clear, uninterrupted communication is essential. SPARK audio technology far outperforms legacy Bluetooth in data throughput, low latency and power efficiency, while enabling lower latency and significantly lower power consumption than Wi-Fi-based audio technologies to ensure longer battery life. “SPARK’s reputation for audio excellence has been embraced by prestigious audio brands from Focal to Sonus Faber,” said Fares Mubarak, Chief Executive Officer, SPARK Microsystems. “Expert analysis now affirms what these brands and their discerning customers already know – SPARK’s wireless audio delivery performance is unrivaled. I’m looking forward to meeting with attendees, customers and stakeholders at AES Show 2024 NY to discuss the future of wireless audio delivery.” AES Show 2024 NY attendees are invited to visit SPARK Microsystems at Booth 542 for live demonstrations of SPARK’s headset demo kit. Audio industry expert Jeff Anderson will present his research and findings on Thursday, October 10, 11AM, in Demo Room 3D04. About SPARK Microsystems​ SPARK Microsystems is building next generation short-range wireless communication devices. SPARK provides high data rate and very low latency wireless communication links at an ultra-low power profile, making it ideal for personal area networks (PANs) used in mobile, consumer and IoT-connected products. Leveraging patented technologies, SPARK Microsystems strives to minimize and ultimately eliminate wires and batteries from a wide range of applications while delivering a wired-like performance. For more information, please visit www.sparkmicro.com.​ Contact Details Jenna Beaucage +1 508-340-6851 jbeaucage@rainierco.com Company Website https://www.sparkmicro.com

October 07, 2024 01:03 PM Eastern Daylight Time

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Direxion Launches Netflix and Taiwan Semiconductor Manufacturing Single Stock Leveraged and Inverse ETFs

Direxion

Furthering their continued success with Single Stock Leveraged and Inverse ETFs, Direxion, a leading provider of tradeable and thematic ETFs, today announced the launch of two additional pairs. These four funds allow active traders to obtain magnified, or inverse, exposure to the daily performance of the common stock of Netflix, Inc., or Taiwan Semiconductor Manufacturing Co., Ltd., through either the Direxion Daily NFLX Bull 2X Shares ( Ticker: NFXL ) and Direxion Daily NFLX Bear 1X Shares ( Ticker: NFXS ), or the Direxion Daily TSM Bull 2X Shares ( Ticker: TSMX ) and Direxion Daily TSM Bear 1X Shares ( Ticker: TSMZ ). “Direxion launched its first two pairs of single stock leveraged and inverse ETFs just over two years ago, amassing more than $3 billion in the expanding suite since,” said Direxion Managing Director, Edward Egilinsky. “Netflix and Taiwan Semiconductor Manufacturing are two of the hottest names in the retail space, lending themselves well to tactical trading in response to potential company events and market sentiment. We look forward to expanding our suite of single stock leveraged and inverse ETFs in the near future.” As ground-breaking products built for active traders, Direxion’s pairs of single stock leveraged and inverse ETFs are meant to be used for short-term trading purposes. Leveraged and inverse single stock ETFs should not be viewed as buy and hold investments, but rather trading tools for traders with a high risk tolerance. In addition, unlike traditional ETFs, or even other levered and/or inverse ETFs, these ETFs track the price of a single stock rather than an index, eliminating the benefits of diversification. All Direxion leveraged and inverse ETFs are intended only for investors with an in-depth understanding of the risks associated with seeking leveraged investment results, and who plan to actively monitor and manage their positions. There is no guarantee these ETFs will meet their objective. Please visit the Direxion Leveraged and Inverse ETF Education Center, where you will find educational brochures, videos, and a self-paced online course to help you understand if leveraged ETFs are right for you. About Direxion: Direxion equips investors who are driven by conviction with ETF solutions built for purpose and fine-tuned for precision. These solutions are available for a broad spectrum of investors, whether executing short-term tactical trades, or investing in thematic strategies. Direxion’s reputation is founded on developing products that precisely express market perspectives and allow investors to manage their risk exposure. Founded in 1997, the company has approximately $48.6 billion in assets under management as of September 30, 2024. For more information, please visit www.direxion.com. There is no guarantee that the Funds will achieve their investment objectives. For more information on all Direxion Shares ETFs, go to www.direxion.com, or call us at 866.301.9214. An investor should carefully consider a Fund’s investment objective, risks, charges, and expenses before investing. A Fund’s prospectus and summary prospectus contain this and other information about the Direxion Shares. To obtain a prospectus and summary prospectus call 866-476-7523 or visit our website at direxion.com. A Fund’s prospectus and summary prospectus should be read carefully before investing. Investing in the funds involves a high degree of risk. Unlike traditional ETFs, or even other leveraged and/or inverse ETFs, these leveraged and/or inverse single stock ETFs track the price of a single stock rather than an index, eliminating the benefits of diversification. Leveraged and inverse ETFs pursue daily leveraged investment objectives, which means they are riskier than alternatives which do not use leverage. They seek daily goals and should not be expected to track the underlying stock’s performance over periods longer than one day. They are not suitable for all investors and should be utilized only by investors who understand leverage risk and who actively manage their investments. The Funds will lose money if the underlying stock’s performance is flat, and it is possible that the Bull Fund will lose money even if the underlying stock’s performance increases, and the Bear Fund will lose money even if the underlying stock’s performance decreases, over a period longer than a single day. An investor could lose the full principal value of his or her investment in a single day. Investing in the Funds is not the same as investing directly in NFLX or TSM. Entertainment Industry Risk — Companies in the entertainment industry may be impacted by the high costs of research and development of new content and services in an effort to stay relevant in a highly competitive industry, and entertainment products may face a risk of rapid obsolescence. Entertainment companies are subject to risks that include cyclicality of revenues and earnings, changing tastes and topical interests, and decreases in the discretionary income of their targeted consumers. Consumer Discretionary Sector Risk — Because companies in the consumer discretionary sector manufacture products and provide discretionary services directly to the consumer, the success of these companies is tied closely to the performance of the overall domestic and international economy. Semiconductor Industry Risk – Semiconductor companies may face intense competition, both domestically and internationally, and such competition may have an adverse effect on such companies’ profit margins. Semiconductor companies may have limited product lines, markets, financial resources or personnel. Companies in the semiconductor industry may have products that face obsolescence due to rapid technological developments and frequent new product introduction, unpredictable changes in growth rates and competition for qualified personnel. Netflix, Inc. Investing Risk – Issuer-specific attributes may cause an investment held by the Fund to be more volatile than the market generally. The value of an individual security or particular type of security may be more volatile than the market as a whole and may perform differently from the value of the market as a whole. As of the date of this prospectus, in addition to the risks associated with companies in the consumer discretionary sector, and more specifically the entertainment industry, Netflix, Inc. faces risks related to maintaining and expanding membership for its streaming services; competition in the entertainment video market; unforeseen costs or liability in connection with content that is acquired, produced, licensed and/or distributed through its service; the ability to manage change and growth in its business; costs and challenges associated with strategic acquisitions and investments; regulatory changes and legal issues; protecting its intellectual property; consumer data privacy issues; and network operators handling and changing data access. Taiwan Semiconductor Manufacturing Co., Ltd. Investing Risk – Issuer-specific attributes may cause an investment held by the Fund to be more volatile than the market generally. The value of an individual security or particular type of security may be more volatile than the market as a whole and may perform differently from the value of the market as a whole. As of the date of this prospectus, in addition to the risks associated with companies in the semiconductor sector, TSM faces risks associated with: the highly competitive nature of the semiconductor industry; economic and market uncertainty; reductions in demand for its products; potential concentration of revenues in a few large clients; geopolitical events and pandemics; adequate protection of technology or other intellectual property; exchange rates; reliance on third parties to manufacture products; possible shortages of equipment or materials needed to manufacture products; cybersecurity attacks and data breaches; system failures or outages; potential incompatibility of product with some or all industry standard software and hardware; increases in costs; adverse government regulations; regulatory compliance costs; litigation; taxes; indebtedness; and the ability to attract and retain high quality talent. Direxion Shares Risks – An investment in each Fund involves risk, including the possible loss of principal. Each Fund is non-diversified and includes risks associated with a Fund concentrating its investments in a particular security, industry, sector, or geographic region which can result in increased volatility. A Fund's investments in derivatives such as futures contracts and swaps may pose risks in addition to, and greater than, those associated with directly investing in securities or other investments, including imperfect correlations with underlying investments or the Fund's other portfolio holdings, higher price volatility and lack of availability. As a result, the value of an investment in a Fund may change quickly and without warning. Risks of the Funds include Effects of Compounding and Market Volatility Risk, Derivatives Risk, Counterparty Risk, Rebalancing Risk, Intra-Day Investment Risk, Netflix, Inc. or Taiwan Semiconductor Manufacturing Co., Ltd. Investing Risk, Market Risk, Industry Concentration Risk, Cash Transaction Risk, Indirect Investment Risk, and risks specific to the consumer discretionary sector, entertainment industry or semiconductor industry. Additional risks include, for the Direxion Daily NFLX Bull 2X Shares and Direxion Daily TSM Bull 2X Shares, Leverage Risk and Daily Correlation Risk, and for the Direxion Daily NFLX Bear 1X Shares and Direxion Daily TSM Bear 1X Shares, Shorting or Inverse Risk as well as Daily Inverse Correlation Risk. Please see the summary and full prospectuses for a more complete description of these and other risks of the Funds. Distributor: ALPS Distributors, Inc. Contact Details Ditto Public Relations Danielle Black, AD direxion@dittopr.co Company Website https://www.direxion.com/

October 03, 2024 09:00 AM Eastern Daylight Time

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Focal Chooses SPARK Microsystems’ UWB Wireless Tech for New HiFi DIVA UTOPIA Speakers

SPARK Microsystems

SPARK Microsystems, a Canadian fabless semiconductor company specializing in next-generation short-range wireless communications, today announced its collaboration with Focal, the renowned French audio brand, in the development of the revolutionary DIVA UTOPIA loudspeaker. This collaboration brings together Focal’s expertise in high-fidelity audio with SPARK’s Ultra-Wideband (UWB) technology, delivering a high-performance wireless audio experience. The DIVA UTOPIA is Focal’s first connected, wireless active loudspeaker, designed to meet the demands of those seeking exceptional sound quality with the convenience of modern wireless technology. SPARK’s SR1020 wireless transceiver leverages UWB technology to supply the data transmission between the two speakers, delivering uncompressed audio with ultra-low latency, setting a new standard for wireless audio performance. “Our collaboration with Focal showcases the advantages of SPARK’s UWB in delivering high-resolution audio without the limitations of traditional wireless technologies,” said Julie Delamarre, SPARK Microsystems, Senior Vice President of Worldwide Sales. “The DIVA UTOPIA is a great example of how a UWB wireless connection ensures every note is transmitted with the highest fidelity.” SPARK’s UWB connectivity allows for a seamless wireless connection between the two DIVA UTOPIA loudspeakers, maintaining a stable and lossless signal at 96kHz/24bit resolution. This advanced technology eliminates the need for wires while preserving the quality of sound typically associated with wired connections. With support for major streaming platforms and wireless protocols, the DIVA UTOPIA offers a versatile and intuitive user experience. SPARK’s UWB technology supports multiroom configurations, making it easier than ever to integrate the DIVA UTOPIA into a complete home music ecosystem. "The DIVA UTOPIA represents a new era in high-fidelity audio. By integrating SPARK Microsystems' UWB technology, we have created a loudspeaker that not only delivers exceptional sound quality but also offers the freedom and flexibility that today’s consumers demand,” said Rejean Bedel, Focal & Naim, Group Marketing Manager. “This partnership is a testament to our commitment to pushing the boundaries of innovation and redefining the listening experience." The DIVA UTOPIA loudspeakers are now available exclusively at qualified Focal Powered by Naim stores. For more information, visit Focal's website. About Focal Since 1979, Focal has stood out from the crowd in manufacturing loudspeakers and acoustic speakers. Their expertise extends to headphones, car audio kits, professional speakers, and installations for yachts. This unique know-how, combined with their in-house manufacturing in France, puts Focal among the top audio brands globally. In 2011, Focal joined forces with Naim — the British leader in high-end electronics — under the VerVent Audio group to offer exquisite complete audio systems. Visit www.focal.com for more. About SPARK Microsystems​ SPARK Microsystems is building next generation short-range wireless communication devices. SPARK provides high data rate and very low latency wireless communication links at an ultra-low power profile, making it ideal for personal area networks (PANs) used in mobile, consumer and IoT-connected products. Leveraging patented technologies, SPARK Microsystems strives to minimize and ultimately eliminate wires and batteries from a wide range of applications while delivering a wired-like performance. For more information, please visit www.sparkmicro.com.​ Contact Details Jenna Desimone +1 508-340-6851 jdesimone@rainierco.com Company Website https://www.sparkmicro.com

October 02, 2024 12:03 PM Eastern Daylight Time

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Market Alert: Silexion Therapeutics (NASDAQ: SLXN) Sees Record Volumes Following Breakthrough Preclinical Data for SIL-204

Global Markets News

Shares of Silexion Therapeutics (NASDAQ:SLXN) are seeing significatnly today after the company announced promising new preclinical data for its next-generation siRNA candidate, SIL-204. The stock saw a significant initial of price spike of over 50% in pre-market activity as investors responded to the latest developments in Silexion's RNA interference (RNAi) platform, which targets KRAS-driven cancers. As of now, volume is at record highs, currently standing at over 50 million shares today. The company revealed that SIL-204, an extended-release microparticle formulation, demonstrated substantial tumor reduction and necrosis in mouse models of pancreatic cancer bearing the KRAS G12D mutation—one of the most common mutations found in pancreatic cancer patients. This latest data builds on a string of recent successes for Silexion, including its September 24 announcement of results from the Phase 2 trial for its first-generation product, LODER™, which showed significant improvements in tumor resectability among non-resectable pancreatic cancer patients. Alongside the new preclinical results, Silexion has recently reported plans to begin toxicology studies for SIL-204 in preparation for Phase 2/3 clinical trials expected to commence in the first half of 2026. The company is also expanding the application of its siRNA technology to colorectal cancer models, reflecting its broader ambitions to target multiple KRAS-driven cancers, which are notoriously difficult to treat with conventional therapies. While stock price has pulled back since premarket, The spike in Silexion’s market activity as marked by these record high volumes (according to market data) may highlight the growing market interest in the company’s novel approach to tackling cancers with high unmet medical needs, particularly its focus on KRAS mutations, which are common across a variety of aggressive cancers, including pancreatic and colorectal cancer. Silexion’s continued momentum in the precision oncology space potentially positions it as a leading player in the development of next-generation RNAi therapies. With its promising pipeline and recent positive developments, the company seems to be gaining attention as it advances toward clinical trials that could offer new hope for patients battling some of the deadliest cancers. Click here to read Silexion's full announcement *** This update is for informational purposes only and is not intended to serve as financial, investment or any form of professional advice, recommendation or endorsement. Please review the full documentation detailing financial compensation disclosures and disclaimers the article is subject to. [https://justpaste.it/ab9dn/pdf]. Global Markets News Network is a commercial digital brand compensated to provide coverage of news and developments related to innovative companies as detailed in the full documentation and it is thus subject to conflicts of interest. Contact Details News Coverage ronald@futuremarketsresearch.com

October 01, 2024 11:47 AM Eastern Daylight Time

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Former USC Student-Athlete L Simpson Launches "Take No L’s" Collection with Shiekh at USC Village

Full Scope PR

Current USC student, former USC football player and fashion entrepreneur L Simpson is rewriting the playbook for student-athletes with the exclusive launch of his highly anticipated streetwear collection, “Take No L’s”, at Shiekh at USC Village on Sept. 26. What began as a middle school project has evolved into a brand that embodies a mindset of relentless determination: no losses, only lessons – whether it’s on the court, field or in life. “Take No L’s” gained significant traction throughout Simpson’s high school basketball career at Sierra Canyon High School (Chatsworth, Calif.), where he captained his team to back-to-back California Open State Championships alongside notable teammates Scottie Pippen Jr., KJ Martin, Cassius Stanley and Christian Koloko. The brand’s momentum continued to increase when he joined USC’s renowned football program. Coached by USC head coach Lincoln Riley alongside former teammates and current NFL players, Caleb Williams, Jordan Addison and Brenden Rice, “Take No L’s” quickly became a regularly worn brand among his teammates and coaches. “I’m thrilled for L,” said USC head coach Lincoln Riley. “It’s always great to watch our players achieve their dreams, both on and off of the field. Whether we’re on campus or around the city, our players and staff love wearing the brand. L is extremely bright and innovate, and I know he is going to be incredibly successful.” “This launch is special,” says Simpson. “I shopped at Shiekh as a kid. Whenever Jordans would drop or when I wanted new athletic gear, I would always ask my parents to take me to Shiekh. It truly does feel like a full- circle moment. We’re not just selling clothes; we’re promoting a mindset of going after your dreams and never accepting defeat. That’s what Take No L’s stands for—no losses, just lessons.” Take No L’s is a bold, confident and unapologetic premium streetwear brand featuring striking graphics and vibrant colors. The collection includes hoodies, cropped sweatshirts, t-shirts, sweatpants and hats, with prices ranging from $90 to $200. With significant attention from L’s influencer network, which boasts a combined reach of over 100 million followers, the brand is already generating buzz on social media. Join Simpson on Sept. 26 from 3 p.m. to 6 p.m. PT at Shiekh in USC Village for the official launch of the “Take No L’s” collection. Experience firsthand why “Take No L’s” is setting a new standard in streetwear. The event will include special appearances, exclusive products and live entertainment featuring stars like Storm Reid, Brenden Rice, Riri Simpson, Jazz Hill, Temi Ojoro, Tade Ojoro, Ceyair Wright, Amber Jasmine, Lboogz, and Saint Thomas. Don't miss this exciting celebration of fashion and culture! About L Simpson: L Simpson, current USC student and former student-athlete, is the founder of the “Take No L’s” brand. Inspired by sports, culture and the journey of perseverance, Simpson created “Take No L’s” to encourage people to live fearlessly and embrace a lifestyle without losses. Simpson’s collection combines bold design, high-quality fabrics and empowering messaging to create a distinctive streetwear line that resonates with today’s generation. L has previously hosted his own talk show on SLAM and recently co-hosted the “Almost Pro” podcast with former Heisman Trophy winner Caleb Williams. Simpson is currently pursuing a degree in communication from the USC Annenberg School of Communication and Journalism, and he will graduate in the spring of 2025. For more info on the brand, visit takenolsstore.com and follow Simpson on Instagram at @lboogz. About Shiekh Shoes: Style Elevated, Sneakers Celebrated. Shiekh offers a curated collection of footwear, apparel, and accessories. Explore top brands like Nike, Adidas, and Jordan at Shiekh. Shiekh stores can be found at premium locations in multiple states. For more information follow @Shiekh on Instagram and visit Shiekh.com Media Contact: Pia Malihi | Full Scope PR pia@fullscopepr.com # # # Contact Details Pia Malihi pia@fullscopepr.com Company Website https://takenolsstore.com/

September 26, 2024 01:12 AM Eastern Daylight Time

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drive21, Van Wagner Collaborate to Elevate In-Venue Branding and Fan Engagement Across College Athletics

drive21

drive21, a leader in experiential design and marketing solutions, today announced a strategic relationship with leading collegiate athletics marketing agency, Van Wagner to become a preferred experiential graphic design and implementation provider for Van Wagner. Van Wagner is recognized for its expertise in collegiate sponsorship sales and multi-media rights and will collaborate with drive21 to redefine branding strategies, drive revenue growth, and create Name, Image and Likeness (NIL) execution opportunities in the collegiate sports industry. Through this relationship, Van Wagner’s collegiate clients will be afforded advantageous pricing and access to drive21’s suite of services to provide innovative branding and design solutions across their venues; driving innovative solutions that bridge the gap between brand aspirations and reality, creating immersive environments that resonate with audiences and drive tangible business results. "This relationship represents a significant step forward in our mission to transform sports and entertainment venues into impactful environments that are also powerful marketing tools," said Warren Godridge, drive21 Founder and President. "By collaborating with Van Wagner, we can leverage our creativity and expertise to deliver a consistent brand experience across all venues, enhancing the value for brands, universities, and fans alike." “Traditional approaches often focus solely on aesthetics and overlook the potential to maximize partnership, sponsorship and NIL opportunities, leaving untapped value on the table” said John Libro, Head of Sports and Entertainment at drive21. “Working with Van Wagner College will allow us to push the boundaries of experiential design and transform collegiate athletic facilities into dynamic revenue-generating tools that engage fans and drive real business growth.” This relationship may also offer an even more comprehensive solution to collegiate clients by providing new NIL revenue streams. Through this collaboration with drive21, a portion of the facility’s expenditure can be reallocated to the universities’ NIL efforts. This allows universities to offer a more engaging experience for athletes and fans while creating dynamic environments supporting athletic performance, fan engagement and brand partnerships. "drive21’s ability to seamlessly integrate brand experiences into our facilities is a game-changer for our clients,” said Mark Donley, Chief Revenue Officer at Van Wagner College. “Through our arrangement with drive21, our university clients have an opportunity to access the expertise of drive21 to not only enhance their facilities but also ensure a consistent and high-quality experience for a variety of initiatives at an advantageous rate. It's truly a win-win-win scenario." The first major joint effort was a collaboration at Florida International University for the brand implementation of the newly named Pitbull Stadium. drive21 and Van Wagner played a key role in creating cohesive branding for the first college athletic venue named after a musician, exampling the transformative potential of experiential design and strategic branding. To learn more about the partnership, or drive21’s sports, entertainment and hospitality solutions, please visit www.drive21.com. About drive21 drive21 elevates the sports, entertainment, and hospitality industries by delivering one-of-a-kind branded venue experiences. A leader in experiential design and marketing solutions, drive21 bridges the gap between imagination and reality to deliver functional and impactful environments through design, fabrication, implementation, and holistic project management. Servicing organizations including MLB, MLS and NCAA institutions, drive21 helps its clients maximize partnership and sponsorship revenue and turns ordinary environments into extraordinary works of art. For more information, visit www.drive21.com. About Van Wagner Van Wagner is a leading sports advertising and entertainment agency with global expertise in filmed and live entertainment, sponsorship sales, multi-media rights, and aerial advertising. Van Wagner creates, advises, and sells for world-class teams, leagues, brands, and properties. An innovator in the sports and media business, Van Wagner is a global leader in high-impact broadcast visible signage throughout the MLB, NBA, NCAA, and international soccer, sponsorships sales, college multi-media rights, and in-venue content production at the world’s biggest sporting events. For more information, visit www.vanwagner.com. Contact Details Hot Paper Lantern Jackson Gaskins jgaskins@hotpaperlantern.com Company Website https://drive21.com

September 25, 2024 08:00 AM Eastern Daylight Time

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AI Unpacks Generational Stereotypes, Highlighting Key Differences, but Beer Bridges the Gap

AIport

What happens when you ask generative AI models to depict Baby Boomers, Gen X, Millennials, and Gen Z? You might expect tech-challenged Boomers and avocado-loving Millennials. But what you get is far more interesting and in some cases, unexpected. A joint research project conducted by AIport and Turing Post last month analyzed over 1200 AI-generated images across four different models—Stable Diffusion, Midjourney, YandexART, and ERNIE-ViLG. The findings have revealed both familiar stereotypes and surprising quirks about how AI perceives these generations. Sad Boomers, Happy Zoomers? Contrary to the carefree Boomer stereotype, AI models like Midjourney depict Baby Boomers as introspective, or even somber, often bundled up and gazing wistfully into the distance—a reflection, perhaps, of their disillusionment with the unfulfilled ideals of the 1960s cultural revolution. However, the ERNIE-ViLG model, likely trained on datasets with a more collectivist cultural slant, shows 93% of Boomers smiling. This fascinating contrast underscores the cultural differences embedded in different AI models. Meanwhile, Gen Z’s images are vibrant and diverse, reflecting their reputation as a generation that embraces individuality, inclusivity, and self-expression. The AI-generated images depict Zoomers in colorful, highly detailed scenarios, making them the most visually distinct generation in the study. Generations Through the AI Lens The research explored how generations are portrayed in five key aspects of life: identity, relationships, work, lifestyle, and consumer habits. The AI models revealed consistent patterns and stereotypes; for example, males predominated in the depictions of Boomers and Gen Xers across all four models, while many images of Millennials and Zoomers showed greater diversity and more female representation. Surprisingly, Gen X appears to be the least well-understood generation by AI, characterized by fewer defining features compared to all other generations, likely due to the limited amount of training data available. The one stereotypical Gen X leitmotif that AI consistently identifies is their fondness for flannel shirts—an unmistakable symbol of the 1990s grunge scene worn by Gen Xers who were rebellious teenagers and young adults during that era. As for one (un)expected commonality… It’s beer. Whether they’re Millennials job-hopping or Boomers reminiscing about the good old days, AI consistently showed beer in 34% of the produced images across all generations. Prompt Engineering and AI Insights The prompts for this research were carefully crafted to avoid bias, using neutral phrases like "A Millennial at work" or "A Boomer relaxing." The results offer a telling look at how generative AI models mirror societal stereotypes, often shaped by the data they're trained on. These findings open the door to deeper discussions on how AI reflects, and sometimes distorts, cultural narratives. "Whether we think we can learn about generations from these images depends upon how confident we feel that the training data that went in is an accurate image of the self identity of a group,” explains Senior Engineer and Sociologist Stephanie Kirmer, who analyzed the findings. “For the younger sets, I don’t think we can know how much of it is media representation created by people outside the group versus how much is selfie-style personal expression. Some of what we’re getting, especially for the older groups who don’t contribute as much self-generated visual media online, is perceptions of that group from advertising and media, which we know has inherent flaws." About the Study The study examined the outputs of four globally recognized generative AI models, each with distinct aesthetic and cultural nuances, providing a comprehensive look at how each generation is portrayed visually. The selected models included Stable Diffusion, Midjourney, YandexART, and ERNIE-ViLG, offering diverse perspectives from different regions across the globe. Conclusion Whether confirming or contradicting societal stereotypes, AI-generated images provide a fascinating snapshot of how technology interprets generational differences. The fact that beer remains a unifying theme across all four models shows that, no matter our age, some things—like enjoying a cold one—transcend generational divides. To learn more about the project, visit https://www.aigenerations.tech/. Hero images for the media: Google Drive Link About AIport AIport is an emerging community of AI/ML enthusiasts and practitioners with a goal of providing a truly global view of the AI/ML/DS landscape. https://www.blog.aiport.tech/ About Turing Post Turing Post is everything you need to make smarter decisions about AI. https://www.turingpost.com/ Contact Details Nick Leighton nick.leighton@nettresultsllc.com Company Website https://www.aigenerations.tech/

September 23, 2024 10:00 AM Eastern Daylight Time

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Siti Non AAMS - Migliori Siti Casino & Scommesse 2024

AM Europe

Sono sempre di più gli utenti italiani che scelgono di scommettere sui cosiddetti siti non AAMS. Questi concessionari operano con licenze internazionali e garanwtiscono l’accesso a generosi bonus senza deposito, a più metodi di pagamento, e a dei giochi che sui siti AAMS solitamente non si trovano. Chiunque sia alla ricerca di siti di scommesse legali in Italia seppur al di fuori della normativa AAMS, in questa guida andremo proprio a fornire una panoramica sui migliori operatori di questo genere. Tabe di Siti Non AAMS & Casino non AAMS Perché gli Italiani Scelgono i Bookmaker Non AAMS Gli italiani scelgono i siti non AAMS per tante motivazioni differenti, che si rifanno principalmente a ciò che riguarda le promozioni, alla selezione di giochi e prodotti disponibili e alla struttura di diverse funzionalità delle piattaforme stesse. Bonus più generosi Meno restrizioni Ampia varietà giochi Programmi VIP esclusivi Tornei giornalieri Lista dei Migliori Siti non AAMS Panoramica Di seguito, proponiamo una lista di quelli che a nostro parere sono i migliori siti non AAMS, con tanto di descrizione dei punti di forza di ciascuno: HappySlots: Questo casinò rappresenta il paradiso per gli amanti delle slot machine, in quanto propone una selezione capace di abbracciare migliaia di titoli differenti. I giocatori possono quindi esplorare una miriade di temi e funzionalità all’interno di HappySlots, portale capace di far provare sempre qualcosa di nuovo ai propri utenti, soprattutto grazie alle frequenti aggiunte di titoli originali. WildTokyo: Perfetto per chi cerca dell’adrenalina su base quotidiana, questo casinò online si ditingue per offrire promozioni e gare con premi che vengono assegnati ogni giorno; infatti, all’interno di questo portale vengono proposte giornalmente nuove sfide e bonus che rendono l’esperienza di gioco sempre dinamica e ricca di opportunità da cogliere per usufruire di ricompense extra. ProntoBet: Con un palinsesto sportivo che non ha nulla da invidiare ai principali bookies mondiali, ProntoBet è sicuramente il sito ideale per gli appassionati di scommesse sportive. L’offerta di ProntoBet copre tutti gli eventi sportivi globali e consente agli utenti di scommettere su una vasta gamma di discipline con quote molto competitive. Winsane: Questo portale è rinomato per il suo eccellente e ben strutturato programma fedeltà; grazie a quest’ultimo, i giocatori più assidui possono beneficiare di bonus esclusivi e trattamenti VIP personalizzati che vanno a premiare la loro fedeltà con vantaggi unici e premi assegnati su misura. Cashwin: Con un’offerta che prevede la fruizione costante di nuove promozioni per nuovi iscritti e utenti già registrati, Cashwin è senza dubbio l’ideale per chi ama passare il proprio tempo nel tentativo di sfruttare al meglio dei bonus vantaggiosi. Le promozioni disponibili sono generose e spesso sono pensate per incrementare percentualmente i fondi di gioco che vengono depositati in maniera davvero significativa. Quickwin: La punta di diamante di Quickwin è costituita dalla lounge dedicata al casinò live, in cui è possibile trovare tutti i giochi con croupier dal vivo. Gli amanti dell’interattività e della dinamicità del casinò potranno trovare un’ampia selezione di titoli in grado di ricreare fedelmente l’ambiente di un casinò reale, soprattutto grazie alla qualità dei giochi offerti. Perchè gli Italiani scelgono i Siti non AAMS Come detto in precedenza, i siti non AAMS stanno rapidamente guadagnando popolarità tra gli scommettitori italiani, poiché offrono una serie di vantaggi che superano quelli dei bookmaker regolamentati dall’AAMS. Grazie a bonus mediamente più generosi, metodi di pagamento che includono anche le criptovalute e selezioni di giochi più estese, questi siti stanno diventando sempre più gettonati. Qui sotto abbiamo preparato un elenco di motivi, dettagliati uno per uno, per i quali gli utenti si stanno spostando sempre più verso queste alternative ai casinò online tradizionali. Bonus e promozioni: I siti non AAMS propongono bonus più generosi rispetto alle controparti regolate dall’AAMS e spesso assicurano anche giri gratuiti e bonus senza deposito che sono sempre molto graditi a tutti gli utenti; Metodi di pagamento: I siti non AAMS supportano molti altri metodi di pagamento come le criptovalute oltre alle opzioni più classiche come possono essere le carte di credito e i portafogli elettronici; Selezione di giochi: Offrendo una gamma di giochi da casinò tendenzialmente più ampia rispetto ai casinò normali, i siti non AAMS si fanno preferire per la maggiore varietà a cui gli utenti possono avere accesso; Licenze e sicurezza: Pur non regolamentati dall'AAMS, i siti non AAMS possiedono licenze internazionali, assicurando elevati standard di sicurezza e protezione per dati personali e transazioni finanziarie. Supporto clienti: Il supporto multilingue dei siti non AAMS, solitamente disponibile tramite chat live, email e telefono, garantisce assistenza immediata che permette di risolvere ogni tipologia di problema efficientemente. Pro e Contro dei Siti Non AAMS Pro: Ampia gamma di bonus, varietà di giochi, flessibilità nei pagamenti e meno restrizioni. Contro: Il servizio clienti di queste piattaforme a volte potrebbe tardare più del dovuto nelle risposte. Cos'è un sito di scommesse sportive non AAMS? Un sito di scommesse sportive non AAMS è una piattaforma che opera senza la licenza italiana rilasciata dall’Agenzia delle Dogane e dei Monopoli, ma che possiede comunque una attestazione internazionale. Questi siti consentono agli utenti di piazzare scommesse sempre sulla maggioranza degli eventi sportivi internazionali, ma offrendo un numero di mercati che generalmente va oltre a quello proposto dai siti AAMS; infatti, come abbiamo già sottolineato, le piattaforme non AAMS sono note per avere regole meno rigide sotto tutti i punti di vista, il che significa spesso limiti di scommessa più alti, bonus più generosi e metodi di pagamento più variegati. Come registrarsi nei Siti non AAMS Registrarsi su un sito di scommesse non AAMS spesso passa da un processo più rapido rispetto a quello che si deve affrontare all’interno dei casinò tradizionali, grazie a procedure meno rigide in termini di raccolta dati. In molti casi, i siti non AAMS consentono di registrarsi con metodi alternativi come Google o Apple ID, in modo da abbattere le tempistiche necessarie per creare un nuovo conto di gioco. Inoltre, al posto della classica procedura di convalida obbligatoria dei documenti entro 30 giorni, come richiesto dai casinò AAMS per evitare la sospensione del conto, i siti non AAMS adottano procedure di Know Your Customer (KYC) meno invasive; questo significa che, anche se il processo di KYC non viene portato a termine correttamente, l'utente può comunque accedere liberamente a tutte le funzionalità del casinò ad eccezione dei prelievi, che vengono resi disponibili solo dopo aver completato questa procedura. Visitare il sito scelto: La prima cosa da fare è recarsi nella homepage del sito di scommesse non AAMS; Cliccare su "Registrati": Successivamente, bisogna cliccare sul pulsante di registrazione che è solitamente piazzato in alto a destra nella pagina principale del sito; Compilare il modulo: Arrivati qui, toccherà all’inserimento dei propri dati personali, come nome, cognome, indirizzo email e numero di telefono; alcuni siti potrebbero richiedere anche la creazione di un nome utente; Verificare l'account: Infine, bisognerà inviare una copia dei documenti richiesti per la verifica dell'identità, passaggio fondamentale per sbloccare la possibilità di effettuare dei prelievi. Giochi da casinò disponibili I siti non AAMS sono particolarmente indicati per gli amanti dei giochi del casinò, in quanto spesso e volentieri sono presenti decine di alternative per ciascuna delle categorie di giochi principali. Giochi da tavolo I giochi da tavolo includono grandi classici come blackjack e baccarat, con molte varianti alternative utili per adattarsi a diversi stili di gioco. Slot Dalle slot tradizionali alle video slot con grafiche particolareggiate, queste piattaforme offrono anche titoli con jackpot progressivi capaci di portare a vincite significative. Casinò live Il casinò live offre un'esperienza estremamente realistica con un croupier reale e include tsvoli di giochi come roulette, blackjack e poker dal vivo. Blackjack Il blackjack è disponibile sia offline live, permettendo ai giocatori di scegliere se giocare a delle partite automatizzate o in diretta con dei croupier. Roulette Le varie versioni di roulette includono quella europea, quella americana e quella francese, con sempre diverse opzioni di scommessa disponibili sia virtualmente che live. I casinò non AAMS sono legali in Italia? Sì, i siti non AAMS sono legali anche in Italia nonostante operino tramite delle licenze internazionali, come possono essere quelle rilasciate da Malta o Curaçao, piuttosto che con licenze AAMS. Questo significa che, pur non essendo regolamentati direttamente dal governo italiano, questi portali possono comunque offrire servizi di scommessa e gioco d'azzardo ai residenti in Italia senza alcuna implicazione a livello legale. Per chiudere, pensiamo sia importante ricordare che, nonostante sia sempre garantito che questi casinò operano legalmente, i giocatori dovrebbero sempre verificare la licenza sotto cui il sito opera per assicurarsi che siano protetti e che i loro fondi siano al sicuro. Metodi di deposito e prelievo Spesso, i siti di scommesse non AAMS danno la possibilità agli utenti di prelevare e versare denaro tramite decine di metodi di pagamenti differenti da quelli solitamente messi a disposizione dai concessionari. Queste piattaforme sono ben consapevoli dell'importanza di effettuare transazioni rapide e sicure, e per questo motivo mettono a disposizione diverse opzioni per soddisfare le esigenze di un pubblico internazionale; che si tratti di carte di credito, portafogli elettronici o bonifici bancari, ogni giocatore può trovare il metodo di pagamento che meglio si adatta alle proprie preferenze e necessità. L'inclusione delle criptovalute in alcuni di questi siti rappresenta un ulteriore passo avanti verso la modernizzazione delle operazioni finanziarie, in modo da garantire non solo velocità, ma anche un alto livello di anonimato e sicurezza. Vediamo ora nel dettaglio quali sono le opzioni di pagamento più comuni disponibili sui siti di scommesse non AAMS. Visa: La carte di credito Visa costituiscono uno dei metodi di pagamento più popolari e diffusi nei siti di scommesse AAMS e non. Visa garantisce che le transazioni siano sempre protette da tecnologie avanzate di crittografia, in modo da ridurre al minimo il rischio di frodi. Inoltre, la velocità delle operazioni consente ai giocatori di avere i fondi disponibili immediatamente per scommettere; tuttavia, è bene ricordare che per alcuni siti potrebbero essere applicate commissioni e che i tempi di prelievo potrebbero variare sulla base delle condizioni imposte dal concessionario. Mastercard: Mastercard è un'altra carta di credito largamente accettata all’interno dei siti non AAMS. Anche questa opzione prevede la stessa rapidità nelle transazioni e la protezione dalle frodi grazie all’utilizzo di sistemi di sicurezza piuttosto avanzati; come per Visa, anche con Mastercard si possono incontrare tempi di attesa per i prelievi che variano a seconda del sito, ma la trasparenza delle commissioni e la velocità nelle operazioni hanno reso questo metodo una scelta molto popolare; Paypal: Paypal è uno dei portafogli elettronici più utilizzati nei siti non AAMS e non. La sua popolarità deriva dalla facilità d'uso della sua interfaccia e dalla velocità di evasione delle transazioni, i cui processi permettono ai giocatori di effettuare depositi e prelievi in pochi click e secondi. Inoltre, ricordiamo che Paypal è sinonimo di un ulteriore livello di sicurezza, in quanto funge da intermediario tra il conto bancario del giocatore e il sito senza che le informazioni sensibili vengano mai condivise direttamente con il casinò. Neteller: Neteller è uno dei portafogli elettronici preferiti dai giocatori che utilizzano i siti non AAMS per via della sua alta velocità e semplicità. Le transazioni con Neteller sono quasi istantanee e permettono di trasferire fondi rapidamente, sia per i depositi che per i prelievi. Inoltre, questo portafoglio elettronico assicura un elevato livello di sicurezza, grazie a sistemi di crittografia avanzati. Bonifico bancario: Operare tramite il bonifico bancario rimane un metodo tradizionale, utilizzato soprattutto da chi preferisce trasferire fondi direttamente dal proprio conto corrente senza l'intermediazione di carte o portafogli elettronici. Anche se questo metodo offre un’elevata sicurezza, grazie al sistema bancario regolamentato, i tempi di elaborazione possono essere più lunghi rispetto ad altre opzioni, richiedendo fino a 5 giorni lavorativi per il completamento di qualsiasi tipo di giocata. Bonus e Promozioni sui Siti non AAMS Uno dei motivi principali per cui molti giocatori scelgono i siti non AAMS sta nella generosità e varietà dei bonus e delle promozioni disponibili. Questi casinò offrono promozioni molto più competitive rispetto ai siti regolamentati dall’AAMS, con cifre spesso superiori, bonus senza deposito, e programmi fedeltà più vantaggiosi. Molti siti non AAMS propongono anche promo come i cashback settimanali o mensili, che permettono di vedersi restituita una percentuale delle perdite subite per via delle giocate non vincenti. Infine, i tornei giornalieri e le race con premi extra sono una caratteristica comune, capace di attirare i giocatori con promozioni dinamiche e costanti. Ecco alcune delle offerte più comuni: Free Spins: Si tratta di gratuiti offerti su slot selezionate, ideali per provare nuovi giochi senza rischiare il proprio denaro. Bonus senza deposito: Uno dei preferiti dai nuovi iscritti, permette di iniziare a giocare senza dover effettuare un deposito con i propri soldi. Wagering: Condizioni di giocata che talvolta sono più favorevoli rispetto ai siti AAMS, consentendo di soddisfare i requisiti di scommessa in modo più semplice. Cashback: Alcuni casinò non AAMS offrono un ritorno percentuale sulle perdite nette, in modo da garantire ai giocatori un piccolo rimborso. Software disponibile sui bookmaker non AAMS I siti non AAMS collaborano con alcuni dei migliori provider di software nel settore del gioco d’azzardo allo scopo di garantire un’esperienza fluida in ogni momento. Questi provider sono responsabili dello sviluppo di giochi equi, con funzionalità innovative e grafiche di alta qualità. Curacao I siti di scommesse con licenza rilasciata dalla giurisdizione di Curacao collaborano con alcuni dei più celebri provider di software della scena, tutto per offrire giochi godibili ed equi. NetEnt Betsoft Evolution Gaming Pragmatic Play Yggdrasil MGA Anche i siti regolati dalla Malta Gaming Authority (MGA) collaborano con fornitori di software leader del settore per assicurare che l’esperienza di gioco sia la migliore possibile. Microgaming Play’n GO Quickspin Thunderkick Evolution Gaming Le Nostre Conclusioni In conclusione, ci siamo convinti del fatto che i siti non AAMS rappresentano senza dubbio un’alternativa valida per chi cerca maggiore libertà, promozioni più generose e un elenco di giochi più fornito rispetto alle disponibilità dei casinò tradizionali. Anche se non regolamentati direttamente dall’AAMS, molti di questi siti operano con licenze riconosciute a livello internazionale che garantiscono inconfutabilmente un livello di sicurezza molto elevato. Tuttavia, ricordiamo che è fondamentale che i giocatori siano consapevoli dei possibili rischi che possono correre e che scelgano piattaforme con una buona reputazione e licenze affidabili come quelle di cui abbiamo parlato all’interno di questa stessa panoramica. Domande Frequenti (FAQ) È sicuro giocare all’interno di un sito non AAMS? Sì, i siti non AAMS che possiedono licenze internazionali come quelle di Curaçao o Malta offrono livelli di sicurezza paragonabili a quelli AAMS. Quali bonus posso ottenere sui siti non AAMS? I siti non AAMS offrono bonus senza deposito, giri gratuiti, cashback e promozioni personalizzate, solitamente in misura maggiore rispetto ai bookmaker AAMS. Posso prelevare le vincite dai siti non AAMS? Sì, i siti non AAMS permettono prelievi tramite carte di credito, portafogli elettronici come Neteller e PayPal, bonifici bancari, criptovalute e non solo. I siti non AAMS sono legali in Italia? Sì, i siti non AAMS sono legali per i giocatori italiani; tuttavia, essendo regolamentati da autorità internazionali, operano al di fuori del sistema di licenze italiano. Contact Details Berardo Bianchi +39 035 0445 9954 Berardo@itsitinonaams.com Company Website https://www.casinolistingonline.com/

September 20, 2024 04:09 AM Eastern Daylight Time

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Industry Update: 3 Exciting Precision Oncology Players to Watch Following Summit’s Meteoric Rise: Silexion, Nuvectis, Scorpian

Global Markets News

Summit Therapeutics (NASDAQ: SMMT) recently captured headlines with the release of its Phase 3 data for ivonescimab, a targeted NSCLC therapy that has generated substantial buzz. The results from its trial conducted in China showed a dramatic 49% reduction in the risk of disease progression or death compared to Merck’s Keytruda, signaling a potentially disruptive force in NSCLC treatment. However, the news wasn’t without its concerns—since the trial data originates from China, there are questions about its applicability to broader, global populations. As noted by BMO Capital Markets’ Evan Seigerman: “Results may or may not be generalizable beyond the China-focused patient population initially assessed.” Despite this, Summit’s valuation has risen by over 100%, now approximating $19 billion. With such a high valuation, the company could see limited room for further significant gains, leading many in the industry to explore other emerging opportunities in precision oncology. Alongside Summit, there are quite a few other players in the field. Some if these companies have even already shown promising initial results and could see similar success in the future if they were to report positive results. These emerging players are worth watching for those interested in following precision oncology drug candidates and pipelines. Among them are precision oncology innovators such as Silexion Therapeutics, Nuvectis Pharma, and Scorpion Therapeutics, which we discuss below. Silexion Therapeutics: Disrupting the KRAS-Driven Cancer Space Silexion Therapeutics (NASDAQ: SLXN) is another under-the-radar player in the precision oncology space, with a focus on KRAS-driven cancers—a notoriously difficult target in oncology. While current small-molecule KRAS inhibitors are making progress, they are often limited to specific mutations, such as KRAS G12C, which accounts for a small percentage of cancers. Silexion’s RNA interference (RNAi) approach offers a broader solution, targeting a wider spectrum of KRAS mutations, particularly in pancreatic cancer, one of the deadliest and most treatment-resistant cancers. At the heart of Silexion’s approach is its LODER™ platform, which delivers siRNA directly to the tumor site, silencing KRAS mutations at the genetic level. This localized delivery not only increases efficacy by concentrating the treatment in the tumor, but it also reduces systemic side effects. Silexion’s next-generation candidate, SIL-204, is an optimized siRNA formulation designed to target pan-KRAS G12x mutations, positioning it to treat a broader range of KRAS-driven cancers beyond pancreatic cancer, such as lung and colorectal cancers. In Phase 2 trials for locally advanced pancreatic cancer, Silexion's LODER™ platform showed a 9.3-month improvement in overall survival when combined with standard chemotherapy. Additionally, the objective response rate (ORR) increased from 20% with chemotherapy alone to 55% with the combination, and in some cases, tumors that were initially non-resectable became operable after treatment with LODER™. These results are especially encouraging given the limited options available for pancreatic cancer patients. SIL-204, is expected to enter Phase 2/3 clinical trials in 2025-2026. What makes Silexion particularly intriguing is its current market valuation. Valued at aproximatly just ~$9 million following its SPAC merger, the company’s valuation could be perceived as low when compared to some of its peers, especially given its innovative technology and promising clinical achievements. Some have wondered whether this low valuation has more to do with dynamics post-SPAC companies. If Silexion can report positive results in its later-stage trials, the company’s outlook could dramatically improve, reflecting the potential of its RNAi-based platform. Like NXP900, SIL-204 could potentially have vast applications across multiple KRAS-driven cancer types, making Silexion a company to watch closely as it advances through clinical development. Nuvectis Pharma: Targeting NSCLC and Beyond by Inhibiting SRC/YES1 Kinases Nuvectis Pharma (NASDAQ: NVCT) has been quietly making strides in the precision oncology sector, developing innovative therapies aimed at overcoming treatment resistance in hard-to-treat cancers. Its lead candidate, NXP900, targets NSCLC by inhibiting the SRC/YES1 kinases, which play critical roles in cancer cell survival and resistance to current therapies. This approach positions NXP900 as a potential game-changer in the treatment of NSCLC, particularly in patients who have developed resistance to EGFR and ALK inhibitors, such as AstraZeneca’s Tagrisso and Novartis’ Alecensa. NXP900 is still in the early stages of clinical development, currently undergoing Phase 1 trials. However, preclinical studies have already shown that it has strong anti-tumor activity in resistant NSCLC models. Even more promising is its potential application beyond NSCLC. Like Summit's ivonescimab, NXP900 focuses on resistance, but it also has broader applications due to its ability to target multiple cancer types driven by SRC/YES1 pathways. This versatility makes it a promising asset not just for NSCLC but also for other difficult-to-treat cancers like squamous cell carcinomas. In addition to NXP900, Nuvectis is advancing NXP800, another precision oncology candidate that is further along in the clinical development process. NXP800 is currently in Phase 1b trials, targeting ARID1a-mutated cancers such as ovarian and endometrial cancers. The early clinical data for NXP800 is promising, showing positive responses in patients with platinum-resistant ovarian cancer. With two strong candidates in the pipeline, Nuvectis is positioning itself as a formidable player in the precision oncology landscape. As Summit’s ivonescimab continues to gain attention, Nuvectis’ earlier-stage NXP900, with its NSCLC focus and beyond, could see similar success in the future if clinical results continue to trend positively. Scorpion Therapeutics: Pioneering Mutant-Selective Therapies Scorpion Therapeutics is redefining the frontier of precision oncology with its focus on delivering highly selective small molecules targeting validated and previously undruggable cancer mutations. Its lead candidate, STX-478, is a mutant-selective, allosteric PI3Kα inhibitor currently in Phase 1/2 trials for advanced solid tumors. Early data presented at the ESMO Congress 2024 highlighted its potential, with STX-478 demonstrating a 23% overall response rate in breast cancer and a 21% response rate across all tumor types, positioning it as a potentially best-in-class PI3Kα inhibitor. STX-478 is notable for its ability to spare wild-type PI3Kα activity in normal tissues, avoiding the toxicities seen with previous PI3Kα inhibitors, such as hyperglycemia and rash. Tumor reductions were seen in 72% of patients treated with STX-478 as a monotherapy, with circulating tumor DNA levels dropping in 86% of patients. This mutant-selective precision could help overcome the limitations of existing PI3Kα inhibitors, which have struggled with dose-limiting toxicities. In July 2024, Scorpion raised $150 million in a Series C financing round, co-led by Frazier Life Sciences and Lightspeed Venture Partners. The additional funding will support the advancement of STX-478 and other pipeline assets, positioning Scorpion for further clinical success. Scorpion’s pipeline includes a broad range of wholly-owned compounds that target both validated and novel cancer targets, positioning the company for future expansion into larger patient populations. As STX-478 progresses through clinical development, Scorpion is poised to become a significant player in the precision oncology space, making it another company worth watching closely. Optimistic Outlook for Precision Oncology The precision oncology space is experiencing a golden era of innovation, with companies like Summit Therapeutics, Nuvectis Pharma, Silexion Therapeutics, and Scorpion Therapeutics leading the charge. As the focus shifts towards targeted therapies that address resistance mechanisms, the market is increasingly favoring companies with novel approaches and broad applications. Summit’s meteoric rise has shown that there is tremendous potential for companies that can demonstrate efficacy in overcoming cancer resistance. While Summit has already captured much of the current attention, companies like Nuvectis, Silexion, and Scorpion, with their earlier-stage pipelines, offer exciting opportunities for the industry to keep a close eye on. As these companies continue to report clinical data and advance through trials, the potential for breakthroughs in treating some of the most difficult cancers grows stronger. With targeted therapies offering the possibility of overcoming resistance without the need for chemotherapy, the future of cancer treatment looks brighter than ever. For those in the oncology space, keeping a close eye on emerging players like Nuvectis, Silexion, and Scorpion could lead to transformative developments as the field of precision oncology continues to evolve. * * * This update may include speculative forward looking statements. Readers are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, and that actual results may differ materially from those in the forward-looking statements as a result of various factors. the BioTech and Pharma industries are volatile and risky and readers are advised to seek out preffesional advice in the relevent feilds from licensed profesionals. This update is for informational purposes only and is not intended to serve as financial, investment or any form of professional advice, recommendation or endorsement. Please review the full documentation detailing financial compensation disclosures and disclaimers the article is subject to. [ https://justpaste.it/ch2qt/pdf ]. Global Markets News Network is a commercial digital brand compensated to provide coverage of news and developments related to innovative companies as detailed in the full documentation and it is thus subject to conflicts of interest. Contact Details News Coverage ronald@futuremarketsresearch.com

September 19, 2024 07:45 AM Eastern Daylight Time

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